Effect of dietary supplementation with resveratrol, alpha-tocopherol and piperine on oxidative stress and inflammation in older adults with risk factors for metabolic syndrome.

ZULMA MANFREDI; ISABEL PASTOR; MANUELA SORENSEN; ROBERTO LEMOLI; FABIANA LAIRION; CHRISTIAN SAPORITO; MATÍAS LASSO; LILA LOPEZ MONTAÑANA; MARISA GABRIELA REPETTO; RAUL PASTOR; ALEJANDRA CIMATO; ALDANA RODRIGUEZ; MARGARITA MARTINEZ SARRASAGUE

CIUDAD AUTONOMA BUENOS AIRES

Congreso; Reunión Anual de Sociedades de Biociencia. SAIC, SAI, AAFE, NANOMED-ar; 2021

SAIC, SAI, AAFE, NANOMED-ar

Oxidative stress, hypertension, blood glucose level and lipid profile are risk factors for metabolic syndrome (MS) and cardiac disease in older adults. The aim of this study is evaluate the protective role of resveratrol supplementation on chronic inflammation and oxidative stress associated to MS. Voluntary patients with a diagnosis of MS (n=92) based on the diagnostic criteria of the National Cholesterol Education Program, Adult treatment Panel III, 2002 received a dietary supplement (RTP: 50 mg resveratrol, 25 mg alpha-tocopherol and 5 mg piperine) along with their usual treatment for a period of 3 months. Piperine increases resveratrol and alpha-tocopherol absorption. Control was the patient himself in baseline conditions, avoiding interindividual variables and bioavailability of active principles. Venous blood was collected from 23 patients (68 ± 5 years), and biochemical markers were assessed in plasma: protein oxidation (measured as carbonyl protein, CO), and interleukin 6 (IL-6); and in red blood cells (RBC): catalase activity. Patients were classified into 3 groups according to the amount of risk factors (blood glucose, HDL cholesterol, triglycerides, waist circumference and blood pressure) for MS: 3/5 (n=7), 4/5 (n=5) and 5/5 (n=11) risk factors. Preliminary results showed increase in catalase activity (22-32%, p