INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
capítulos de libros
Mitochondria as a mediator of cell death
BUSTAMANTE J.; LORES ARNAIZ S.
Free Radicals in Pathophysiology
Lugar: Trivandrum; Año: 2008; p. 129 - 145
Apoptosis is an important type of cell death characterized by the induction of different signalling pathways in which the mitochondrial participation is frequently observed. Changes in mitochondrial normal functioning, lead to the amplification of the proteolytic cascade which mediates the degradation of cellular substrates including the typical chromatin fragmentation process. Mitochondrial permeabilization of its inner or outer membranes seems to be a critical event. These mitochondrial membrane permeability changes occur as consequence of a closely coordinated alteration of other different mitochondrial functions in which nitric oxide (NO) has an important participation.