Left ventricular hypertrophy does not prevent heart failure in experiment hypertension

CAO G; OTTAVIANO G; GELPI R; GOMEZ LLAMBI H; SUAREZ D; B BUCHHOLZ; MILEI J; M DONATO; MULLER ANGÉLICA DEL CARMEN; OTERO-LOSADA, MATILDE

INTERNATIONAL JOURNAL OF CARDIOLOGY

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2017 p. 57 - 65

0167-5273

Int J Cardiol. 2017 Jul 1;238:57-65. doi: 10.1016/j.ijcard.2017.03.109. Epub 2017 Mar 27.Left ventricular hypertrophy does not prevent heart failure in experimental hypertension.Hernán Gómez Llambí H1, Cao G1, Donato M2, Suárez D1, Ottaviano G1, Müller A1, Buchholz B2, Gelpi R2, Otero-Losada M3, Milei J1.Author informationAbstractBACKGROUND:Left ventricular hypertrophy (LVH) secondary to hypertension has been accepted to prevent heart failure (HF) while paradoxically increasing cardiovascular morbi-mortality.OBJECTIVES:To evaluate whether antihypertensive treatment inhibits LVH, restores beta-adrenergic response and affects myocardial oxidative metabolism.METHODS:Ninety spontaneously hypertensive rats (SHR) were distributed into groups and treated (mg/kg, p.o.) with: losartan 30 (L), hydralazine 11 (H), rosuvastatin 10 (R), carvedilol 20 (C). Hypertension control group comprised 18 normotensive rats (Wistar-Kyoto, WKY). Following euthanasia at 16months, contractility was measured in 50% of rats (Langendorff system) before and after isoproterenol (Iso) 10-9M, 10-7M and 10-5M stimulation. Left ventricular weight (LVW) was measured in the remaining hearts, and normalized by BW. Expression of thioredoxin 1 (Trx-1), peroxyredoxin 2 (Prx-2), glutaredoxin 3 (Grx-3), caspase-3 and brain natriuretic peptide (BNP) was determined.RESULTS:Systolic blood pressure (mmHg): 154±3 (L), 137±1 (H), 190±3 (R)*, 206±3 (SHR)*, 183±1 (C)**, and 141±1 (WKY) (*p