IBIMOL 23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
artículos
Título:
Iron and Copper Toxicity in Rat Liver: A Kinetic and Holistic Overview
Autor/es:
ACOSTA, JUAN MANUEL; SAPORITO MAGRIÑA, CHRISTIAN; REPETTO, MARISA GABRIELA; MUSACCO SEBIO, ROSARIO; BOVERIS, ALBERTO
Revista:
LIVER RESEARCH
Editorial:
Openventio Publishers
Referencias:
Lugar: WASHINGTON; Año: 2017 vol. 2 p. 9 - 13
ISSN:
2379-4038
Resumen:
Iron (Fe) and copper (Cu) overloads in rats showed a dose and time dependent metal accumulationin liver with its associated toxicity. The increased contents of the transition metals markedly enhanced the endogenous free-radical mediated processes of phospholipid peroxidation. Invivo liver chemiluminescence showed an increased production of 1 O2, and a consumption ofreduced glutathione (GSH), the main intracellular antioxidant. Results fit with a Haber-Weiss type molecular mechanism in which Fe or Cu and endogenously produced O2- and H2O2, yield HO radical that initiates free-radical mediated phospholipid peroxidation and protein oxidation.
