IBIMOL 23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
artículos
Título:
Mitochondrial nitric oxide synthase: a master piece of metabolic adaptation, cell growth, transformation and death
Autor/es:
FINOCCHIETTO PV; FRANCO MC; HOLOD S; GONZÁLEZ AS; CONVERSO DP; ANTICO ARCIUCH VG; SERRA MP; PODEROSO JJ; CARRERAS MC
Revista:
EXPERIMENTAL BIOLOGY AND MEDICINE
Editorial:
SOC EXPERIMENTAL BIOLOGY MEDICINE
Referencias:
Lugar: Maywood; Año: 2009 vol. 234 p. 1020 - 1028
ISSN:
1535-3702
Resumen:
Mitochondria are specialized organelles that control energy metabolism, and also activate a multiplicity of pathways that modulate cell proliferation and mitochondrial biogenesis or oppositely, promote cell arrest and programmed cell death by a limited number of oxidative or nitrative reactions. Nitric oxide regulates oxygen uptake by reversible inhibition of cytochrome oxidase, and the production of superoxide anion from the mitochondrial electron transfer chain. In this sense, NO produced by mtNOS will set the oxygen uptake level and contribute to redox-dependent cell signaling. Modulation of translocation and activation of neuronal nitric oxide synthase (mtNOS activity) under different physiological or pathological conditions represents an adaptive response properly modulated to adjust mitochondria to different cell challenges.
