IBIMOL 23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
artículos
Título:
Pancreatitis Promotes Oncogenic KrasG12D-Induced Pancreatic Tranformation Through Activation of NUPR1
Autor/es:
DANIEL GRASSO; GARCIA MARÍA NOÉ; TEWFIKHAMIDI; CARLA CANO; EZEQUIEL CALVO; GWEN LOMBERK; RAUL URRUTIA; JUAN L IOVANNA
Revista:
Molecular & Cellular Oncology
Editorial:
LANDES BIOSCIENCE
Referencias:
Lugar: Austin; Año: 2014 vol. 1 p. 29913 - 29913
Resumen:
During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncogenes by lowering the tumor suppressive threshold of oncogene-induced senescence through expression of the stress protein Nupr1.
