IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
artículos
Título:
QSAR Applications During Last Decade on Inhibitors of Acetylcholinesterase in Alzheimer's Disease
Autor/es:
WONG, K. Y.; DUCHOWICZ, PABLO R.; MERCADER, ANDREW G.; CASTRO, EDUARDO A.
Revista:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Lugar: Oak Park; Año: 2012
ISSN:
1389-5575
Resumen:
This article reviews multi-criteria QSAR applications on
Acetylcholinesterase inhibitors as palliative drugs for Alzheimer's
Disease, published in the period 2001-2011. It includes QSAR models for
different series of compounds, comparative studies, and advances in
methodologies. This period is marked by a shift in focus from palliative
treatment to pathogenesis. However, we believe that research into
palliative treatment should continue. More comparative studies are
desirable. In order to facilitate comparative and general studies on
Acetylcholinesterase inhibitors, a standard experimental protocol for
measuring an inhibitor's potency is needed. Finally, we recommend
chemists to work closely with system and molecular biologists.