IBIMOL   23987
INSTITUTO DE BIOQUIMICA Y MEDICINA MOLECULAR PROFESOR ALBERTO BOVERIS
Unidad Ejecutora - UE
artículos
Título:
Carotenoides en quimioprevencion:
Autor/es:
ARTURO A. VITALE; EDUARDO BERNATENE; ALICIA B. POMILIO
Revista:
ACTA BIOQUíMICA CLíNICA LATINOAMERICANA
Editorial:
FEDERACION BIOQUIMICA PROVINCIA BUENOS AIRES
Referencias:
Año: 2010 vol. 44 p. 195 - 238
ISSN:
0325-2957
Resumen:
Fruits and vegetables are a rich source of carotenoids, which provide health bene:ts reducing the risk of several diseases, including certain cancers, cardiovascular and eye diseases, supported by extensive epidemiologic observation. Carotenoids that have been studied in this regard are beta-carotene, lycopene, lutein and zeaxanthin. The rapid and large amount of experimental evidence has established that a diet containing tomato or products based on tomato results in a decrease of several types of cancer. This fact has stimulated extensive laboratory and clinical research as well as much commercial and public enthusiasm. However, evidence is controversial. The work of these authors on antioxidant compounds, especially in structural and bioactivity terms, has led to analyse whether the bene:cial effects of lycopene are primarily due to its antioxidant properties or other possible mechanisms may be involved, such as the modulation of gap junctional intercellular communications, hormonal and immune systems, and metabolic pathways. In this paper, structural points of view, the antioxidant activity of lycopene, its content in tomatoes, other bioactive components, the possible mechanisms of action and their impact on prostate, colon, breast and endometrium cancer are discussed, according to case-control, cohort and epidemiological studies.