Neurological disorders in an elderly cohort that experienced past stressful events: a retrospective-prospective study

DOMINGUEZ, RAUL; DE LA OSA ANGULO, L; SERRA, JORGE; OUDKERK, L; REPETTO MG; MARSCHOFF, ENRIQUE; VILLAMIZAR PEREZ, S

Current Aging Science

Bentham Science

Lugar: Indianapolis; Año: 2021

ObjectiveTo assess the effects of stressful events in patients who later developed ischemic stroke, Alzheimer´s or Parkinson´s disease.BackgroundPsychological stress may be a risk factor for dementias but the association between exposure to stressful life events and the development of cognitive dysfunction has not been conclusively demonstrated. We hypothesize that if a stressful event has an impact on the subjects, its effects would be different in the three diseases.Material and MethodsTogether with demographic variables (age, sex, race, socioeconomic and cultural levels), five types of previous stressful events were recorded in 1024 patients with Alzheimer´s, Parkinson´s diseases and Ischemic Stroke: death or serious illness of close relatives, job dismissal, change of financial status, retirement, and change of residence. Time-to-Diagnosis (months from the event to the first symptoms: retrospective study) and Evolution time (years of follow-up of each patient: prospective study) were recorded. Analysis of variance and non-parametric methods were applied to the variables Time-to-Diagnosis and Evolution-Time to analyze differences between these diseases.ResultsThe demographic variables age, sex, race, economic and cultural levels resulted statistically non significant; differences in economic level were significant (P Stroke), and minor differences (P