L925I mutation in the para-type sodium channel is associated with pyrethroid resistance in Triatoma infestans from the Gran Chaco Region

CAPRIOTTI N; MOUGABURE CUETO G; RIVERA POMAR R; ONS S

PLOS NEGLECTED TROPICAL DISEASES

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2014 vol. 8 p. 1 - 5

1935-2735

Background:Chagas? disease is an important public health concern in Latin America. Despite intensive vector control effortsusing pyrethroid insecticides, the elimination ofTriatoma infestanshas failed in the Gran Chaco, an ecoregion that extendsover Argentina, Paraguay, Bolivia and Brazil. The voltage-gated sodium channel is the target site of pyrethroid insecticides.Point mutations in domain II region of the channel have been implicated in pyrethroid resistance of several insect species.Methods and Findings:In the present paper, we identify L925I, a new pyrethroid resistance-conferring mutation in T.infestans. This mutation has been found only in hemipterans. In T. infestans, L925I mutation occurs in a resistant populationfrom the Gran Chaco region and is associated with inefficiency in the control campaigns. We also describe a method todetect L925I mutation in individuals from the field.Conclusions and Significance:The findings have important implications in the implementation of strategies for resistancemanagement and in the rational design of campaigns for the control of Chagas? disease transmission