IDACOR   23984
INSTITUTO DE ANTROPOLOGIA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
NAT2 gene diversity and its evolutionary trajectory in the Americas
Autor/es:
BISSO-MACHADO, R.; ACUÑA-ALONZO, V.; GRANARA, A.A.S.; PAIXÃO-CÔRTES, V.R.; SANDOVAL, J.R.S.; BORTOLINI, M.C.; HÜNEMEIER, T.; RAMALLO, V.; DEMARCHI, D.A.; SALZANO, F.M.
Revista:
PHARMACOGENOMICS JOURNAL
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Año: 2016 vol. 16 p. 559 - 559
ISSN:
1470-269X
Resumen:
N-acetyltransferase 2 (NAT2) is responsible for metabolizing xenobiotics; NAT2 polymorphisms lead to three phenotypes: rapid, intermediate and slow acetylators. We aimed to investigate NAT2 diversity in Native Americans. NAT2 exon 2 was sequenced for 286 individuals from 21 populations (Native American and American Mestizos). Excluding the basal/rapid haplotype NAT2∗4, the most frequent haplotypes are NAT2∗5B (35.95%) in hunter-gatherers and NAT2∗7B (20.61%) and NAT2∗5B (19.08%) in agriculturalists that were related to the slow phenotype. A new haplotype was identified in two Amerindians. Data from the ∼44 kb region surrounding NAT2 in 819 individuals from Africa, East-Asia, Europe and America were used in additional analyses. No significant differences in the acetylator NAT2 haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering, probably because of the absence or weakness of selection pressures and presence of demographic and random processes preventing detection of any selection signal.
rds']