IDACOR   23984
INSTITUTO DE ANTROPOLOGIA DE CORDOBA
Unidad Ejecutora - UE
artículos
Título:
Admixture and Population Structure in Central Argentina Assessed by Ancestry Informative Markers
Autor/es:
GARCÍA ANGELINA; DARIO A. DEMARCHI; TOVO-RODRIGUES L; CALLEGARI-JACQUES S,
Revista:
GENETICS AND MOLECULAR BIOLOGY
Editorial:
SOC BRASIL GENETICA
Referencias:
Año: 2015 vol. 38 p. 324 - 324
ISSN:
1415-4757
Resumen:
The population of Argentina has already been studied with regard to several genetic markers, but much more data are needed for the appropriate definition of its genetic profile. This study aimed at investigating the admixture patterns and genetic structure in Central Argentina, using biparental markers and comparing the results with those previously obtained by us with mitochondrial DNA (mtDNA) in the same samples. A total of 521 healthy unrelated individuals living in 13 villages of the Córdoba and San Luis provinces were tested. The individuals were genotyped for ten autosomal ancestry informative markers (AIMs). Allele frequencies were compared with those of African, European and Native American populations, chosen to represent parental contributions. The AIM estimates indicated a greater influence of the Native American ancestry as compared to previous studies in the same or other Argentinean regions, but smaller than that observed with the mtDNA tests. These differences can be explained, respectively, by different genetic contributions between rural and urban areas, and asymmetric gene flow occurred in the past. But amost unexpected finding was the marked interpopulation genetic homogeneity found in villages located in diverse geographic environments across a wide territory, suggesting considerable gene flow.
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