TRANSCRIPTOMIC ANALYSIS IN BLV-EXPERIMENTALLY INFECTED CATTLE LEADING TO HIGH OR LOW PROVIRAL LOAD

LUTZELSCHWAB, CLAUDIA; JULIARENA, MARCELA; GUTIÉRREZ, SILVINA ELENA; FORLETTI, AGUSTINA

Paraná

Congreso; 54 Annual Meeting Society for Biochemistry and Molecular Biology; 2018

Sociedad Argentina de Investigación en Bioquímica y Biología Molecular

Bovine Leukemia Virus (BLV) is a highly prevalent pathogen causing a fatal lymphoproliferative disease in the bovine species. Afterexperimental infection, proviral load peaks at 30 days post infection (dpi), then, cattle progress to two different phenotypes: one is characterizedby high proviral load (HPL) in peripheral blood, while the other is identified by low proviral load (LPL) in peripheral blood. In LPL cattle asharp decrease in proviral load is evidenced at 38 dpi. We studied the transcriptome in peripheral blood cells from 10 cattle (5 of each phenotype)infected with BLV at 38 dpi, to identify the host genes differentially expressed in those animals that progress to LPL, recognized as BLVresistant.RNA seq experiments showed 499 genes differentially expressed (p