CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Fosfomycin residues in colostrum: Impact on morpho-physiology of suckling piglets
Autor/es:
FERNÁNDEZ PAGGI, MARÍA BELÉN; MARTÍNEZ, GUADALUPE; PÉREZ, DENISA SOLEDAD; DIEGUEZ, SUSANA; RICCIO, M. BELÉN; DENZOIN-VULCANO, LAURA; AMANTO, FABIÁN ANDRES; TAPIA, MARÍA OFELIA; SORACI, ALEJANDRO LUIS
Lugar:
Nantes
Reunión:
Congreso; AEVPT 13th International Congress of the European Association for Veterinary Pharmacology and Toxicology; 2015
Institución organizadora:
European Association for Veterinary Pharmacology and Toxicology
Resumen:
Ingestion of colostrum containing antimicrobial residues canalter the proper development of piglet´s intestine, causingmorpho-physiological changes which would negatively impact on its futureproductive life. Irrational use of antibiotics can bring about imbalance onmicrobiota diversity causing diarrhea and even death. The aim of this study wasto determine the effects of fosfomycin residues found in colostrum onintestinal morpho-physiology and microbiota of suckling piglets.Farrow wasinduced in 18 sows at 114 days of gestation. 9 received 15 mg/Kg BW disodiumfosfomycin (Fosbac®, Bedson S.A., Argentina) via IM; and 9 were used ascontrol. Piglets were monitored during the first 24 hs of life at maternityroom (PPS, Pro Surveillence System®). Colostrum production and intake werecalculated using the equation developed by Devillers et all. (2007). 8 pigletswere selected at random from treated sows and divided into 2 groups: A:euthanasia was done after 12 hs of lactation and B: euthanasia was done after24 hs of lactation. Likewise 8 piglets were selected from control sows anddivided into groups C and D where euthanasia took place at 12 and 24 hsrespectively. Intestine samples were collected to determine bacteriology (CFULactobacillus and Enterobacteria) and histology (absorption surface area). Forstatistical analysis software PROC MIXED and GLM del SAS V9.3 wasused.Colostrum/milk production by the sows and its intake by the litter were2921 and 294.2 mL accordingly. Fosfomycin average ingestion per piglet was 0.27mg/Kg BW. No significant interactions between Enterobacteria were observed forthe different groups ((p>0.05). Bacterial count for Lactobacillus wasgreater at 24 hs than at 12 hs (7.55±0.19 y 6.64±0.3 respectively). Nosignificant interactions between groups were detected by histological studies(p>0.05). Measured absorption surface areas were between 10.30 and 6.30 µm2in all groups. Results show that ingestion of colostrum containing fosfomycinresidues would not have an impact on intestinal microbiota balance of neonatalpiglets. This can be explained by phisico-chemical properties of thisantibiotic and its low distribution to mammary fluids. Therefore fosfomycin canbe considered to be safe for treatment of gestating sows during farrowing andlactation.