CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Differential molecular characterization of Fasciola hepatica in several hosts of Cajamarca, Perú. His implication in the development of anthelmintic resistance
Autor/es:
SCARCELLA S.; FIEL C.; SILVA DIAZ H.; ORTIZ OBLITAS P.; SOLANA HUGO
Lugar:
Perth-Western Australia
Reunión:
Congreso; 24th International Conference of the World Association for the Advancement of Veterinary Parasitology (WAAVP 2013).; 2013
Institución organizadora:
The Australian Society of Parasitology.
Resumen:
Fasciolosis caused by the trematode Fasciola hepatica is a parasitic disease prevalent in ruminants raised in temperate regions of the world. This parasitism is maintained in the field for their ability to infect different species such as cattle, sheep or pig among others. It is economically important with losses due to infection estimated as US$ 2000?3000 million yearly. The infection affects up to the 75% of dairy cattle raised in the northern region of Cajamarca, Peru. Furthermore, fasciolosis is an emergent zoonotic disease in many countries, including this region of Peru, where has been reported a prevalence of 24.4% in school children. Given the epidemiological and economic importance of this disease, it is necessary to have information relating to genetic variants in this trematode. Using the RAPD-PCR technique, inthis paper we evaluate the molecular characteristics of adult flukesfrom three different hosts, sheep, cattle and pigs. We compared the genetic profiles of F. hepatica from different hosts detecteda differential expression of polymorphic fragments (RAPD) between the species under study. The results obtained confirm a high level of polymorphism in the genome of F. hepatica showing a manifest genetic variability between flukes fromdifferent hosts.   It is valid postulate that this polymorphism enhanced the adaptability in the host and at the environment. For any selection pressure, whether natural or artificial (bad use of fasciolicides and / or control and management measures), the existence of different genetically distinct populations within the species, allow one or more populations of F. hepatica can survive and create resistance or adaptability to this selective pressure.