WITHDRAWAL TIME OF FOSFOMYCIN IN PIGS AND BROILER CHICKENS AFTER ORAL AND INTRAMUSCULAR ADMINISTRATION

D.S. PÉREZ, A.L. SORACI, M.O. TAPIA

Congreso; Eurotox 2013; 2013

Eurotox

Fosfomycin (FOS) is a broad spectrum bactericidal antibiotic used in veterinary and human medicine due to its low toxicity and potential efficacy. It is widely used in Central-South America and Asia for the prevention and treatment of pulmonary and enteric infections of pigs and chickens. FOS pharmacokinetics has been studied in several species, including humans, birds, rabbits, cattle, dogs, horses and pigs. However, the withdrawal time (WDT) of this antibiotic has not been established yet for intensive production animals, particularly pigs and broiler chickens. The administration of veterinary drugs in food-producing animals, without an adequate WDT can lead to not allowed levels of residues in food for human consumption. Maximum Residue Limits (MRLs) for various drugs have been determined by regulatory agencies in some countries. For FOS, the only known MRL (0.5 mg/mL) was set by Japan for residues in cattle muscle, liver and kidney