Anticestodal and antitrematodal drugs

VIRKEL, G.; ALVAREZ, L.; LANUSSE, C.

Veterinary Pharmacology & Therapeutics

Wiley Blackwell

Lugar: New York; Año: 2018; p. 1081 - 1101

Anticestodal drugs used to treat tapeworm infectionsmay act as either taeniafuges or taeniacides. The formercompounds facilitate tapeworm expulsion from the host,whilst the later cause the death of the tapeworm in situ.Because the cestode?s scolex is capable of regenerating anentire organism, drugs that merely remove the proglottids or the whole tapeworm body but leave the scolexintact are unsatisfactory. Insufcient drug diffusion intothe scolex and consecutive two or three proglottids, dueto the inflammatory reaction of the intestinal mucosa,may account for such a limited cestocidal activity. Theusual interval from destrobilization to patency is approximately 3 weeks, so the recommended interval for evaluating tapeworm therapy is ∼3 weeks after initial drugtreatmen