Macrocyclic lactones: endectocide compounds

IMPERIALE, F; LANUSSE, C; LIFSCHITZ, A

Veterinary Pharmacology and Therapeutics

Wiley

Año: 2017; p. 1102 - 1128

General pharmacology: avermectins and milbemycinsMechanism of action: ecto-endoparasiticidal activityPharmacokinetics -Exchange between bloodstream and target tissues -Metabolism. Bile and intestinal excretion. Involvement of drug transport systems. Pharmacokinetic-pharmacodynamic relationshipTherapeutic uses: animal species-specific considerationsResistanceAvailable pharmaceutical preparationsDrug and host-related factors affecting pharmacokinetics and efficacy in ruminantsTissue residues. Withdrawal timesSafety and toxicityEcotoxicological impactConcluding remarks