CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
capítulos de libros
Título:
Melatonin as a new therapeutic strategy for feline uveitis treatment.
Autor/es:
DEL SOLE, MARÍA JOSÉ; ROSENSTEIN, RUTH ESTELA; SANDE, PABLO HORACIO
Libro:
Felines: Common Diseases, Clinical Outcomes and Developments in Veterinary Healthcare
Editorial:
Nova Science Publishers Inc.
Referencias:
Lugar: New York; Año: 2015; p. 99 - 127
Resumen:
Uveitis is the most common form of
intraocular inflammation and a disease with potentially blinding sequels. Since
the disease causes significant morbidity and the use of traditional forms of
treatment is restricted by limited effectiveness and considerable side effects,
uveitis remains a challenging field to veterinary ophthalmologists. Current
understanding of the role of oxidative and nitrosative stress in ocular
inflammatory diseases indicates that antioxidant and antinitridergic therapy
may be important to optimize the uveitis treatment. Several lines of evidence
strongly support that melatonin is a potent antioxidant molecule which is
effective in scavenging free radicals that are generated in ocular tissues, and
it inhibits the retinal nitridergic pathway. In view of the fact that melatonin
lacks significant adverse collateral effects even at high doses, melatonin
could potentially protect ocular tissues by effectively scavenging free
radicals and excessive amounts of NO generated in the uveitic eye. This chapter
summarizes recent investigations showing that melatonin prevents clinical,
biochemical, ultrastructural and functional consequences of experimental
uveitis, and which support the role of melatonin as a therapeutic strategy for
uveitis treatment.