Bovine Leukemia Virus Non-Productive Infection of Human Mammary Epithelial Cells (MCF10A)

A LENDEZ, PAMELA; NIETO FARIAS, MARIA VICTORIA; CERIANI, MARIA CAROLINA; A SHEAHAN, MAUREEN; L DOLCINI, GUILLERMINA; CERIANI, MARIA CAROLINA; A SHEAHAN, MAUREEN; L DOLCINI, GUILLERMINA; CUESTA, LUCÍA MARTÍNEZ; RR ROWLAND, RAYMOND; CERIANI, MARIA CAROLINA; CUESTA, LUCÍA MARTÍNEZ; RR ROWLAND, RAYMOND; CERIANI, MARIA CAROLINA; A LENDEZ, PAMELA; NIETO FARIAS, MARIA VICTORIA

Clinical Oncology and Research

Science Repository

Año: 2020 vol. 3 p. 1 - 4

2613-4942

Bovine leukemia virus (BLV) is a retrovirus that causes lymphosarcoma in cattle. Some researchers suggest that BLV could be related to breast cancer development, however, evidence that the virus can infect the human counterpart is lacking. For that reason, the objective of this study was to infect in vitro a human mammary epithelial cell line (MCF10A) with BLV. The results suggest that the infection is non-productive, since only a fragment of the viral gene pol was detected in the cellular DNA. These results are consistent with previous studies, where fragments of different BLV genes were found in human mammary tissue. Future studies should investigate whether this non-productive infection can be associated with human breast cancer.