CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
In vitro inhibition of the hepatic S-oxygenation of the anthelmintic albendazole by the natural monoterpene thymol in sheep
Autor/es:
LIFSCHITZ, ADRIAN LUIS; LANUSSE, CARLOS EDMUNDO; MIRÓ, VICTORIA; ROCHA, CAROLINA; VIRKEL, GUILLERMO LEÓN; VIVIANI, PAULA; COSTA, LIVIO; LIFSCHITZ, ADRIAN LUIS; LANUSSE, CARLOS EDMUNDO; MIRÓ, VICTORIA; ROCHA, CAROLINA; VIRKEL, GUILLERMO LEÓN; VIVIANI, PAULA; COSTA, LIVIO
Revista:
XENOBIOTICA
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Año: 2020 vol. 50 p. 408 - 414
ISSN:
0049-8254
Resumen:
Combinations of bioactive phytochemicals with synthetic compounds have been suggested as promissory tools for the improvement of nematode control in livestock. Bioactive phytochemicals may interfere with the activity of drug-metabolizing enzymes and delay the metabolic conversion of anthelmintics into less potent metabolites. This research assessed the effect of the monoterpene thymol (TML) on the in vitro hepatic metabolism of the anthelmintic albendazole (ABZ) in sheep. Liver microsomes from four (4) Texel lambs were incubated with ABZ (50 µM) in absence or in presence of TML (0.05?10 mM). The concentration of TML producing a 50% decrease in ABZ S-oxygenation (IC50) was 13.5 mM. The FMO-dependent S-oxygenation of ABZ was markedly inhibited by the monoterpene (54.1 ± 11.6%, p