Expression of Arginine Vasopressin Type 2 Receptor in Canine Mammary Tumours: Preliminary Results

BIANCHI, C.P.; BIANCHI, C.P.; ABA, M.A.; ABA, M.A.; BENAVENTE, M.A.; BENAVENTE, M.A.

JOURNAL OF COMPARATIVE PATHOLOGY

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2020 vol. 179 p. 36 - 40

0021-9975

The aims of this study were to investigate the potential association of arginine vasopressin type 2 receptor (AVPR2) in canine mammary tumours with expression of oestrogen receptors a (ORa) and b (ORb) and clinicopathological features of the neoplasms. Twenty-six canine mammary tumour samples (11 benign, 15 malignant) were immunolabelled for AVPR2, ORa and ORb antigens. Moderate to intense immunolabelling of AVPR2 antigen, found in all neoplasms, was not significantly associated with expression of ORa or ORb antigens or with clinicopathological features. These findings indicate a potential role for AVPR2 in the development of canine mammary tumours and the use of AVPR2-selective vasopressin analogues as therapeutic options.