CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Differential expression of cyclins mRNA in neural tissues of BoHV-1- and BoHV-5- infected cattle
Autor/es:
MARIN, MAIA; ROSALES, JUAN JOSÉ; MARIN, MAIA; ROSALES, JUAN JOSÉ; BURUCÚA, MERCEDES; ODEÓN, ANSELMO; BURUCÚA, MERCEDES; ODEÓN, ANSELMO; RENSETTI, DANIEL; PÉREZ, SANDRA; RENSETTI, DANIEL; PÉREZ, SANDRA
Revista:
MICROBIAL PATHOGENESIS
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Año: 2019 vol. 136
ISSN:
0882-4010
Resumen:
Bovine alphaherpesvirus types 1 (BoHV-1) and 5 (BoHV5) are closely related alphaherpesviruses. BoHV-5 causes non-suppurative meningoencephalitis in calves. BoHV-1 is associated with several syndromes and, occasionally, can cause encephalitis. Although both viruses are neurotropic and they share similar biological properties, it is unknown why these alphaherpesviruses differ in their ability to cause neurological disease. Neural tissue samples were collected from BoHV-1- and BoHV-5-intranasally inoculated calves during acute infection, latency and reactivation and the levels of cyclins mRNA expression were analyzed by qRT-PCR. Striking differences in the levels of cyclins mRNA were particularly detected in trigeminal ganglion (TG). The expression levels of cyclins in TG during BoHV-5 latency suggest that these viruse sutilize different strategies to persistin the host. It is apparent that are lationship between virus loads and cyclin mRNA levels can be established only during acute infection and other factors might be involved in the regulation of cell cycle components during BoHV latency and reactivation. Bovine alphaherpesviruses neuropathogenicity might be influenced by the differential control of cell cycle components by these herpesviruses. This is the first reporton BoHV-5 modulation of cyclins expression in neural tissues from its natural host.