Fosfomycin residues in colostrum: Impact on morpho-physiology and microbiology of suckling piglets

MARTÍNEZ, G.; DECUNDO, J. M.; TAPIA, M. O.; MARTÍNEZ, G.; DECUNDO, J. M.; TAPIA, M. O.; DIÉGUEZ, S. N.; RICCIO, M. B.; SORACI, A. L.; DIÉGUEZ, S. N.; RICCIO, M. B.; SORACI, A. L.; FERNÁNDEZ PAGGI, M. B.; PÉREZ GAUDIO, D. S.; AMANTO, F. A.; FERNÁNDEZ PAGGI, M. B.; PÉREZ GAUDIO, D. S.; AMANTO, F. A.

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

WILEY-BLACKWELL PUBLISHING, INC

Año: 2018 p. 415 - 427

1365-2885

Fosfomycin is a broad-spectrum bactericidal antibiotic widely used in pig farms for thetreatment of a wide variety of bacterial infections. In this study, the elimination ofdisodium fosfomycin in colostrum/milk of the sow and the impact of this antibiotic onthe microbiota and intestinal morpho-physiology of suckling piglets were analyzed.The average amount of fosfomycin eliminated in colostrum (after administration of15 mg/kg IM) during the first 10 hr postpartum was 0.85 μg/ml, and the mean residualamount ingested by the piglets was 0.26 mg/kg. The elimination profile of fosfomycinconcentrations in colostrum occurs at a time of profound changes in the morphophysiologyof the gastrointestinal tract of the piglet. However, the studied concentrationsdid not produce imbalances on the microbiota or on the morpho-physiology ofthe gastrointestinal tract of the piglet. Concentrations of fosfomycin were maintainedin the mammary gland above the MIC for more than 8 hr for pathogenic bacteria ofproductive importance. This would indicate that fosfomycin may be considered safefor the specific treatment of bacterial infectious processes in sows during the peri- andpostpartum period. This first study with disodium fosfomycin stimulates awareness inthe proper use of antimicrobials at farrowing.