MECHANISM OF ACTION OF DRUGS WITH ACTIVITY AGAINST MULTICELLULAR PARASITES

C. GIORDANI,1 G. H. MARIN,2,3* D. PEREZ,1 A. SORACI,13 J. ERRECALDE

Parazitologiia Parazitology

Nauka

Lugar: Sankt-Peterburg ; Año: 2017 vol. 51 p. 294 - 316

0031-1847

Parasiticides have been the most valuable weapons to combat parasites for almost half acentury, constituting more than 50 % of veterinary pharmaceuticals and a good part of theproducts destined for human health. However, in many parts of the world, parasites developresistance to these drugs, and it is now a major health problem. One way to avoid this inconvenienceis the in-depth knowledge of its mechanisms of action, which will allow amore appropriate use. This work is a review of the different physiological aspects of parasitespecies and an explanation of the different mechanisms of action of antiparasitic agents.Once these drugs are ingested or absorbed by parasites the agents come into contactwith the parasites structures, and according to the drug´s properties it will define the antiparasiticactivity either by altering tegument, carbohydrates, protein and lipid metabolism, ormotility of the multicellular parasites