Intracellular Concentrations of Fosfomycin in Alveolar Macrophages from Weaning Piglets

D.S. PÉREZ, A.L. SORACI, M.O. TAPIA

Research Journal of Veterinary Sciences

Academic Journals Inc.

Año: 2015 vol. 8 p. 29 - 35

At weaning, piglets are more susceptible to infectious diseases, being respiratory syndromesone of the most frequent conditions. Fosfomycin is indicated for the treatment of a variety ofporcine bacterial pathogens, with MIC90 ranging between 0.25-0.50 μg mLG1. Fosfomycin exhibitsa time-dependent killing. Thus, killing of bacteria occurs when its concentrations remain constantlyabove the MIC. Fosfomycin concentrations in respiratory cells and epithelial lining fluid of pigshave already been studied. Although, fosfomycin showed clinical efficacy in the treatment ofpulmonary diseases, concentrations in alveolar macrophages (biophase for facultative and obligateintracellular microorganisms) have not been established in any species. The present studydetermined the intracellular concentrations of disodium fosfomycin in alveolar macrophagesafter a single IM dose of 15 mg kgG1 in the gluteal muscle. Concentrations ranged from0.14-1.52 μg mLG1, being lower than those found in epithelial lining fluid (49.03%) and respiratorycells (54.48%). The Cmax was 1.52 μg mLG1 and Tmax was 4 h. Concentrations exceeded the MIC90 formost pathogens of importance in pig production for up to six hours (T>MIC = 6 h). Therefore,fosfomycin may be useful in the treatment of lung infections caused by facultative intracellularmicroorganisms.