CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Effects of feeding on the plasma disposition kinetics of the anthelmintic albendazole in laying hens.
Autor/es:
BISTOLETTI, M., ALVAREZ, L., LANUSSE, C., MORENO, L.
Revista:
BRITISH POULTRY SCIENCE
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Londres; Año: 2014 vol. 55 p. 824 - 829
ISSN:
0007-1668
Resumen:
1. To optimize the use of ABZ as an anthelmintic in hens, the effects of fasting and type of diet on the plasma kinetics of ABZ and its metabolites were evaluated. 2. Twenty four hens were distributed into four groups: Experiment I: Fed-group fed ad libitum; Fasted-group was fasted over a 12 h period. Experiment II: Pelleted-group fed with pelleted commercial food; Grain-group fed with cereal grains. All groups were treated with ABZ by oral route. Blood samples were taken and plasma analysed by HPLC. 3. ABZ and its metabolites ABZSO and ABZSO2 were recovered in plasma in all the groups. The 12 h fasting period did not modify the disposition kinetics of ABZ in hens. The type of feed affected ABZ kinetics. ABZSO concentration profile was higher and detected longer in the Grain-group compared to the Pelleted-group. Statistical differences were not found for AUC0-∞ values, meanwhile the T1/2for and T1/2el were different between groups. 4. Factors affecting ABZ kinetic behaviour should be considered to optimise its use to ensure the sustainability of the limited available anthelmintic therapeutic tools in avian parasite control.