Oxfendazole flukicidal activity in pigs

ORTIZ, P; TERRONES, S; CABRERA, M; HOBAN, C; CEBALLOS, L; MORENO, L; CANTON, C; DONEDEU, M; LANUSSE, C; ALVAREZ, L

ACTA TROPICA

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2014

0001-706X

tAlthough oxfendazole (OFZ) is a well know broad-spectrum benzimidazole anthelmintic, the assessmentof its potential trematodicidal activity remains unexplored. OFZ administration at single high doses hasbeen recommended to control Taenia solium cysticercus in pigs. The current study investigated the fluki-cidal activity obtained after a single high (30 mg/kg) oral dose of OFZ in pigs harbouring a natural Fasciolahepatica infection. Sixteen (16) local ecotype pigs were randomly allocated into two (2) experimentalgroups of 8 animals each named as follow: Untreated control and OFZ treated, in which animals receivedOFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg. At seven (7) days post-treatment, allthe animals were sacrificed and direct adult liver fluke counts were performed following the WAAVPguidelines. None of the animals involved in this experiment showed any adverse event during the study.OFZ treatment as a single 30 mg/kg oral dose showed a 100% efficacy against F. hepatica. In conclusion,the trial described here demonstrated an excellent OFZ activity against F. hepatica in naturally infectedpigs, after its administration at a single oral dose of 30 mg/kg.