Exposure variability of fosfomycin administered to pigs in food or water: 4 Impact of social rank

ALEJANDRO SORACI

RESEARCH IN VETERINARY SCIENCE

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2013 p. 1 - 7

0034-5288

The objective of this study was to document the effect of social ranking on the internal exposure of pigs to 28 an antibiotic (fosfomycin) administered either in food or in drinking water. Signs of aggression were 29 recorded at the feeder and drinker. The interindividual variability explained by the social rank was even 30 greater when the test antibiotic was given in food despite the fact that the water consumption was less 31 variable than the food intake. The range of plasma concentrations after administration of fosfomycin 32 either in food or drinking water leads to a number of pigs in the treated group being exposed to rather 33 low and highly variable concentrations of fosfomycin and not able to maintain adequate plasma concen- 34 trations above the typical minimum inhibitory concentration (MIC). Social rank clearly influences the 35 level of exposure of pigs to fosfomycin both in food and drinking. However, its administration in drinking 36 water is likely to be the best option to optimize antibiotic efficacy