CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Increase of gluthatione S-transferase, carboxyl esterase and carbonyl reductase in Fasciola hepatica recovered from triclabendazole treated sheep
Autor/es:
SCARCELLA, S; SOLANA, V; FERNANDEZ, V; LAMENZA, P; CEBALLOS, L; SOLANA, H
Revista:
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 p. 63 - 65
ISSN:
0166-6851
Resumen:
Fasciolasis is a zoonotic parasitic disease caused by Fasciola hepatica and its control is mainly based on the
use of triclabendazole (TCBZ). Parasite resistance to different anthelmintics is growing worldwide, including
the resistance of F. hepatica to TCBZ. In the present work we evaluate ?in vivo? the activity of xenobiotic
metabolizing enzymes of phase I (carboxyl esterases) and phase II (glutathione S-transferases and carbonyl
reductases) recovered of flukes from sheep treated with TCBZ. All three enzymes showed increased
activity in TCBZ flukes returning 60 h post-treatment at similar to baseline unexposed flukes. TCBZ action
may induce secondary oxidative stress, which may explain the observed increment in activities of the
analyzed enzymes as a defensive mechanism. The enzymes analyzed are candidates to participate actively
in the development of resistance at TCBZ in F. hepatica.