CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
artículos
Título:
Resistance of Fasciola hepatica against Triclabendazole in cattle in Cajamarca (Peru): A clinical trial and an in vivo efficacy test in sheep
Autor/es:
ORTIZ OBRITAS P.; SCARCELLA S.; CERNA C.; ROSALES C.; CABRERA M.; GUZMAN M.; LAMENZA P.; SOLANA H.
Revista:
VETERINARY PARASITOLOGY
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2013 p. 1 - 12
ISSN:
0304-4017
Resumen:
Fasciolosis caused by Fasciola hepatica, is the most prevalent parasitic disease in dairy cattlefrom the northern region of Cajamarca, Peru. The control of this parasite is based on theuse of Triclabendazole (TCBZ), a drug that has been used for more than fifteen years inthis area. Recent studies, however, have reported a lack of clinical efficacy after treatingdairy cattle. This research was aimed to determine the efficacy of TCBZ in a clinical trial.Eleven dairy cows all positive to F. hepatica identified by presence of eggs in feces, weretreated with TCBZ (Fasinex® 10%) at 12 mg/kg body weight. Fourteen and thirty days aftertreatment, the animals were analyzed for F. hepatica eggs in their feces by the fecal eggcount reduction test. The results found show an overall efficacy of 31.05% and 13. 63%(14 and 30 days post treatment, respectively). Furthermore, an in vivo efficacy test wasconducted in sheep with metacercariae obtained from eggs isolated from a cow clinicallyresistant to TCBZ. Eleven sheep divided in two groups, a control group with no treatment(n = 5) and a treated group (n = 6) were all infected with two hundred metacercariae. Onehundred and six days after infection all the animals demonstrated F. hepatica eggs in theirfeces, confirming the presence of adult parasites in their livers. The animals were thentreated with TCBZ (Fasinex® 10%) at 10 mg/kg body weight. Fifteen days later, the animalswere sacrificed and the number of F. hepatica in their livers counted. The results of thisexperiment showed an efficacy of the flukicide of 25.2% confirming the resistance to TCBZof the F. hepatica isolated from dairy cattle in Cajamarca, Peru.© 2013 Elsevier B.V. All rights reserved.