A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles.

L. MORENO, M.T. LÓPEZ URBINA, C. FARÍAS, G. DOMINGUE, M. DONADEU, B. DENEGRI, H.H. GARCÍA, L.A. GÓMEZ-PUERTA, C. LANUSSE, A.E. GONZÁLEZ.

FOOD AND CHEMICAL TOXICOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2012 vol. 50 p. 3819 - 3825

0278-6915

Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO(2)), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the withdrawal period for human consumption were reported. Forty-eight pigs allocated into two groups received OFZ (30mg/kg) orally as a commercial (CF) or as experimental formulation (SMF). Samples (blood, muscle, liver, kidney and fat) were collected over 30days post-treatment and analyzed by HPLC. OFZ was the main compound recovered in plasma, followed by FBZSO(2) and low FBZ concentrations. OFZ AUC(0-LOQ) (209.9±33.9μg·h/ml) and C(max) (5.40±0.65μg/ml) parameters for the CF tended to be higher than those for the SMF (AUC(0-LOQ): 159.4±18.3μgh/ml, C(max): 3.80±0.35μg/ml). The highest total residue (OFZ+FBZSO(2)+FBZ) concentrations were quantified in liver, followed by kidney, muscle and fat tissue. FBZSO(2) residue levels were the highest found in muscle (0.68±0.39μg/g) and fat (0.69±0.39μg/g). In liver and kidney the highest residues corresponded to FBZ (5.29±4.36μg/g) and OFZ (2.86±0.75μg/g), respectively. A withdrawal time of 17days post-treatment was established before tissues are delivered for human consumption.