INVESTIGADORES
GOLDIN Andrea Paula
artículos
Título:
BDNF is essential to promote persistence of long-term memory storage.
Autor/es:
PEDRO BEKINSCHTEIN; MARTÍN CAMMAROTA; CYNTHIA KATCHE; LEANDRO SLIPCZUK; JANINE I. ROSSATO; ANDREA GOLDIN; IVAN IZQUIERDO; JORGE H. MEDINA
Revista:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Editorial:
NATL ACAD SCIENCES
Referencias:
Año: 2008 vol. 105 p. 2711 - 2716
ISSN:
0027-8424
Resumen:
Persistence is a characteristic attribute of long-term memories (LTMs). However, little is known about the molecular mechanisms that mediate this process. We recently showed that persistence of LTM requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Here,weshow that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis. Importantly, we demonstrate that BDNF induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner. Thus, BDNF is not only necessary, but sufficient to induce a late postacquisition phase in the hippocampus essential for persistence of LTM storage.