IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Polyphenols loaded nanogels design for Zika infection treatment
Autor/es:
GARCIA CC*; MARQUEZ AB; ALAIMO A*
Reunión:
Congreso; Nanomed-ar; 2020
Institución organizadora:
Asociación Argentina de Nanomedicina
Resumen:
Zika virus (ZIKV) infection has been associated with congenital malformations in infectedfoetuses and severe neurological and ocular abnormalities. Currently, there are no specificvaccines or antivirals available to treat this flavivirus; so the management and control ofinfections depend mainly on preventive measures. In this context, polyphenolic compounds [e.g.Resveratrol (RES) and Baicalein (BAI)] exert beneficial properties, including antioxidant, anti-inflammatory, and antiviral activities. Nevertheless, the use of polyphenols handles severalchallenges, such as their poor stability, solubility, and bioavailability. These obstacles could besolved by the application of nanotechnology. In this sense, we planned to encapsulate RES andBAI into chitosan-based nanogels. From a pharmaceutical point of view, chitosan has greatpotential for being biodegradable, biocompatible, and non-toxic, as well as antimicrobialactivity. In addition, it stands out for its high mucoadhesion which is a key property ofnanosystems capable of exerting a controlled release of the bioactive carried. The nanogels willbe prepared by ionic gelation by using TPP as cross-linking agents. Finally, cytotoxicity and antiviral activity of these nanosystems against ZIKV infection will be evaluated in human retinal cells.