IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Altered gene expression in medial prefrontal cortex correlates with social cognition deficits derived from perinatal malnutrition in a mouse model
Autor/es:
TREJO MARTÍNEZ, MARÍA F.; FESSER, ESTEFANÍA A.; BERARDINO, BRUNO G.; GIANATIEMPO, OCTAVIO; CÁNEPA, EDUARDO T.
Lugar:
Villa Carlos Paz
Reunión:
Congreso; XXXIV Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2019
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias (SAN)
Resumen:
Early life adversities such as perinatal malnutrition can modulate neuronal plasticity contributing to neurophysiologic and behavioral alterations. However, mechanisms mediating these effects are not completely known. The aim of this work was to evaluate the impact of perinatal malnutrition on social cognition. We used CF1 dams fed with normal (NP, casein 20%) or low protein diet (LP, casein 8%) during pregnancy and lactation. Offspring were analyzed at PD56. Preclinical PET analysis showed an altered activity in the prefrontal cortex (mPFC) of LP mice suggesting a deficit in the function of this brain?s region. The mPFC is involved in the regulation of social cognition.We found that contextual recognition memory, social interaction and social memory were impaired in LP mice. Conversely, LP mice exhibited an increased dominance hierarchy.To investigatethe potential contribution of E/I imbalance in the mPFC to these behaviors, we evaluate the expression of genes involved in Gabaergic and Glutamatergic transmission. LP mice expressed higher levels of Gria1 and Vglut1 than their NP counterparts. In addition, expression of HDAC2, 5, 7, 10 and 11 were decreased in LP mice. Immunoblot analysis revealed global changes in repressive histone marks H3K9me3 and H3K27me3 and activator mark H3K4me3.We propose that alteration of epigenetic mechanismsduring brain development caused by perinatal malnutrition could lead to altered E/I balance and subsequent deficits in the social domain.