IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
SHORT ALCOHOL CONSUMPTION IMPAIRS THE OFFSPRING HEALTH IN MICE
Autor/es:
ALCAIN JULIETA; CAMBIASSO MAITE; CALVO JUAN CARLOS; GOTFRYD LUCILA; VERMEULEN MÓNICA; NAGUILLA ZAIRA; SALAMONE GABRIELA; STINSON MARCELO G; VANZULLI SILVIA; ERLEJMAN ALEJANDRA; FONTANA VANINA ANDREA
Lugar:
Buenos Aires, Argentina
Reunión:
Congreso; IFPA-SLIMP; 2019
Institución organizadora:
IFPA-SLIMP
Resumen:
Previously, we observed that male alcohol consumption delayed embryodifferentiation by deregulating peri-implantation events and altering embryo trophoblastand inner cell mass morphology in vitro.Objective: To evaluate the effects of paternal alcohol consumption on theoffspring in mice. Methods: CF-1 male mice were exposed (treated group) ornot (control group) to 15% (v/v) ethanol in drinking water ad libitum for 15 days. Control and treated males were mated withnon-treated CF-1 females (1:1), and pregnant females (vaginal plug: day1) were determined.Pregnancy outcome was evaluated and litter mortality, weight and size registered.Blood from adult offspring was analyzed in a Coulter counter. Then, they weresacrificed and dissected. Offspring´s spleen was weighed and analyzedhistologically. Spleen cell populations were determined by flow cytometry. Results:After 21 days of pregnancy, born mice from both groups were registered and, duringthe first week after birth, an increased number of deaths from treated group(p