IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
A High Throughput approach to delineate protein complexes in Formalin- Fixed Paraffin-Embedded Prostate Adenocarcinoma and Benign Prostatic Hyperplasia tissues
Autor/es:
VALACCO, PÍA; SCORTICATTI, CARLOS; VAZQUEZ, ELBA SUSANA; BIZZOTTO, JUAN ANTONIO; SANCHIS, PABLO ANTONIO; NEMIROVSKI, SERGIO; GUERON, GERALDINE; LAGE VICKERS, SOFÍA; MAZZA, OSVALDO; COTIGNOLA, JAVIER
Lugar:
Mar del plata
Reunión:
Congreso; Reunión Anual de la Sociedad Argentina de Investigación Clínica 2019; 2019
Institución organizadora:
SAIC
Resumen:
Introduction: Prostate cancer (PCa) is a progressive disease involving multiple gene alterations; however, little isknown at the proteome level. Most of the functional information of the cancer-associated genes relies in theproteome, a complex biological system with dynamic interactions. We carried out an in-depth proteomicsanalysis to identify differential protein complexes associated with PCa.Methods: PCa and Benign Prostatic Hyperplasia (BPH) samples were obtained from the Hospital de Clínicas ?Joséde San Martín? (with written informed consent and institutional review board approval). Samples were subjectedto mass spectrometry analysis (ESI-MS/MS). To identify protein complexes differentially expressed we usedCORUM, a database of human protein complexes.Results: We identified the following differentially expressed protein complexes in PCa compared with BPH(P
