IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Perinatal and adolescent protein malnutrition have different effects on cognition in adult mice
Autor/es:
BALLARINI, F; IGAZ LM; BERARDINO BG; CÁNEPA ET; CHERTOFF M
Reunión:
Congreso; XXXIV Reunión Anual de la Sociedad Argentina de Investigación en Neurociencias (SAN); 2019
Resumen:
Exposure to environmental adversities, whether it occurs during the perinatal period, childhood, adolescence or adulthood, has an impact on brain regions involved in cognition and mental health. The effects of these adversities on brain and behavior arise as a function of the timing and duration of the exposure and its co-occurrence with the development of specific regions (life cycle model of stress). Here we explore the behavioral phenotypes derived from two nutritional stress paradigms: a low-protein perinatal diet during gestation and lactation (E0-P21), and a low-protein diet during adolescence (p25-P56). Locomotor and exploratory activity, recognition memory and aversive memory were measured in CF-1 8-week-old mice subjected to perinatal malnutrition (LP-P) or adolescent malnutrition (LP-A), and their respective controls (NP-P and NP-A).We found a reduced exploration in LP-P and LP-A mice compared to controls, although locomotor activity was not altered. Declarative recognition memory was impaired only in LP-P mice. Interestingly, aversive memory was not altered in LP-P mice but resulted to be enhanced in LP-A mice. Considering the stress-inoculation theory, we hypothesized that protein malnutrition during adolescence represents a challenging but still moderate stressful environment, which promotes active coping in face of later adversity.In conclusion, our results indicate that while perinatal malnutrition impairs recognition memory, adolescent malnutrition enhances aversive memory showing dissimilar adaptative responses.