Resveratrol nanoencapsulation for a new application in Age-Related Macular Degeneration

DI SANTO, M.C.; GARCÍA LIÑARES, G.; ALAIMO, A.; DOMINGUEZ RUBIO, A.P.; PÉREZ, O.E.; BUOSI, F.S.; MARTÍNEZ, K.D.; CHAUFAN, G.

Paris

Conferencia; Joint Event on Euro Structural Biology, Clinical Trials and NanoPharma. 15th International Conference and Exhibition on Nanomedicine and Pharmaceutical Nanotechnology.; 2019

Conference series LLC Ltd and iMedPub Ltd

Age-related macular degeneration (AMD) is a progressive retinal disease and is the leading cause of visual impairment in elderly people in western countries, for which there is still no cure. Genetics, environmental insults, and age-related issues are risk factors for the development of the disease, and, all these are linked to oxidative stress induction. Also, degeneration of retinal pigment epithelial cells (RPE) is a crucial causative factor responsible for the onset and progression of AMD. With the population aging, AMD will gradually become in a globally prevalent disease. The decline in the quality of life among affected patients highlights a critical need for developing preventive strategies. In this sense, phytochemicals with both antioxidant and anti-inflammatory properties may have a potential role in the prevention and treatment of this ocular disease. Particularly, there is an increased interest in the therapeutic effects of Resveratrol (RSV). RSV is a naturally occurring polyphenolic compound from the stilbenes family, mainly found in black grape and peanuts. RSV has beneficial effects on human health, including its neuroprotection, anti-inflammatory action, potent antioxidant activity and antiaging effects. Our research line is focused in investigating the protective effectiveness of RSV in an in vitro model of AMD. In addition, we designed and developed chitosan-based nanocarriers for RSV encapsulation to overcome physicochemical and pharmacokinetic limitations such as poor oral bioavailability, low water solubility and photosensibility. In summary, chitosan nanoparticles are a promising platform for ocular bioactives (eg. RSV) delivery for therapeutic intervention against oxidative stress-associated diseases, such as AMD.