Mechanism involved in the stimulatory action of erythropoietin on promigratory effect of tumor necrosis factor - alpha

CHAMORRO, MARÍA EUGENIA; VITTORI, DANIELA C.; SCHIAPPACASSE AGUSTINA; MALTANERI, ROMINA E.; NESSE, ALCIRA B.

Mar del Plata

Congreso; LXIII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA; 2018

Sociedad Argentina de Investigación Clínica (SAIC)

The proliferation and migration of endothelial cells are vascular outcomes of inflammation and in this sense, proinflammatory cytokines may enhance the effects of other promigratory factors. Previously, we found that a stimulatory effect of TNF-α on endothelial cells (migration, adhesion, VCAM, ICAM) was enhanced by the simultaneous treatment with erythropoietin (Epo). Based on this, we were interested in investigating the mechanisms involved. Migration of endothelial EAhy.926 cells induced by TNF-α was enhanced by the interaction of Epo+TNF-α, despite no effect of Epo alone was detected at 10 IU/mL (E vs. ET, P