IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Evidence of autophagy dysregulation on microglial cells in the context of Alzheimer?s disease using in vitro and in vivo models.
Autor/es:
GOROJOD ROXANA MAYRA; BENTIVEGNA MELISA; BONIFACINO JUAN S.; ALAIMO AGUSTINA; PRESA JESICA; BEAUQUIS JUAN; SARAVIA FLAVIA; POMILIO CARLOS; VINUESA ANGELES; PORTE ALCON SOLEDAD; KOTLER MÓNICA LIDIA
Lugar:
Ciudad Autónoma de Buenos Aires
Reunión:
Encuentro; GLIA 2017: "The role of glial cells in health and disease of the Nervous System: Clinical and Basic Science walking together"; 2017
Resumen:
Alzheimer?s disease (AD) is the principal cause of dementia in the elderly. A recognized hallmark of AD is the aggregation of Amyloid-β peptides (Aβ) into senile plaques, frequently surrounded by hypertrophied glial cells. We studied microglial alterations in the hippocampus of PDAPP mice, a well-established transgenic model of AD. Before detection of amyloid deposits in the brain, we found an early increase in the Iba1+ soma related area and activation score (p