Evaluation of the anti-parasitic activity of cinchona alkaloids and bile acids compounds against different DTUs of Trypanosoma cruzi.

DANIEL MUSIKANT; LUCIA R. FERNANDEZ; MARTIN M. EDREIRA; DIANA BERNAL; JORGE PALERMO; GABRIEL FERRI; AURÉLIE LEVERRIER

Ciudad Autónoma de Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedades de Biociencias de Argentina

Current pharmacological treatment (i.e. Benznidazol and Nifurtimox)against Trypanosoma cruzi, the etiological agent of Chagas´Disease, showed to be highly toxic and not effective in the chronicstage of the disease. With the objective to find alternative treatmentsagainst the disease, numerous works have demonstrated thatquinolone derivatives compounds have cytotoxic activity againstparasites. Our data showed that compounds of a library of 16 hybridsof Cinchona alkaloids (Quinine, Quinidine, Cinchonine y Cinchonidine)and bile acids (lithocholic and chenodeoxycholic acids)have an anti-parasitic activity against epimastigotes and trypomastigotesof the CL Brener strain. Because of the high genetic variabilitythat this parasite presents, we aimed to extend our study to anotherstrain from a different discrete typing unit (DTU). With this aim, epimastigotesof the Y strain were treated with the same compoundsthan the CL Brener strain, in concentrations ranging from three tofour times the IC50 for CL Brener strain. Our data showed that onlythree compounds presented anti-parasitic activity (p