IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The IL-17F rs763780 SNP is associated with human tuberculosis susceptibility and disease severity in Argentina.
Autor/es:
SANTILLI MARIA C; MORELLI MARIA P; LEVI ALBERTO; PELLEGRINI JOAQUIN M; CASTELLO FLORENCIA A; CASCO NICOLAS; GARCÍA VERÓNICA E; ROLANDELLI AGUSTIN; AMIANO NICOLAS O; TATEOSIAN NANCY L; PALMERO DOMINGO J
Lugar:
CABA
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biosciencias; 2017
Resumen:
Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. In this work, we investigated the association of the IL-17F rs763780 SNP (TC), which generates a protein that is a natural IL-17F antagonist, with tuberculosis disease in Argentina. We found that individuals carrying the C allele were overrepresented in the TB population (TB N=201; HD N= 200; p