Target-Pathogen: un enfoque bioinformático para priorizar blancos drogables en patógenos

FERNANDEZ DO PORTO, DARIO AUGUSTO; PARDO, AGUSTÍN M.; MARTI, MARCELO ADRIAN; SOSA, EZEQUIEL JORGE; TURJANSKI, ADRIAN G.; BURGUENER, GERMAN F.

Buenos Aires

Congreso; 18th international congress of infectious disease; 2018

18th international congress of infectious disease

Available genomic data for pathogens has created new opportunities for drug discovery and development to fight them, including new resistant and multiresistant strains. In particular structural data must be integrated with both, geneinformation and experimental results. Here, we present Target-Pathogen database (http://target.sbg.qb.fcen.uba.ar/), designed and developed as an online resource that allows the integration and weighting of protein information suchas: function, metabolic role, off-targeting, structural properties including druggability, essentiality and omic experiments, to facilitate the identification and prioritization of candidate drug targets in pathogens. We include in the database10 genomes of some of the most relevant microorganisms for human health (Mycobacterium tuberculosis, Mycobacterium leprae, Klebsiella pneumoniae, Plasmodium vivax, Toxoplasma gondii, Leishmania major, Wolbachia bancrofti,Trypanosoma brucei, Shigella dysenteriae and Schistosoma Smanosoni) and show its applicability. New genomes can be uploaded upon request.