THE IL-17F rs763780 SNP IS ASSOCIATED WITH HUMAN TUBERCULOSIS SUSCEPTIBILITY AND DISEASE SEVERITY IN ARGENTINA.

AGUSTÍN ROLANDELLI; NICOLÁS O. AMIANO; NANCY TATEOSIAN; DOMINGO J. PALMERO; JOAQUIN M. PELLEGRINI; FLORENCIA CASTELLO; NICOLAS CASCO; VERÓNICA E. GARCIA; SANTILLI CECILIA; MARÍA PAULA MORELLI; ALBERTO LEVI

Cidad Autónoma de Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias 2017; 2017

SAI - SAIC- SAIB- SAA- SAB- SAFE- SAH- SAP- SAFIS

Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. In this work, we investigated the association of the IL-17F rs763780 SNP (TC), which generates a protein that is a natural IL-17F antagonist, with tuberculosis disease in Argentina. We found that individuals carrying the C allele were overrepresented in the TB population (TB N=201; HD N= 200; p