IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Nanovehicles design for bioactive compuonds
Autor/es:
OSCAR E PÉREZ
Lugar:
Barcelona
Reunión:
Congreso; 3rd World Congress on Materials Science & Engineering; 2017
Institución organizadora:
Scientific Future Group, Redefining Science
Resumen:
Physicochemical and biochemical characterization results crucial for the nanovehicles design which could run as bioactive compounds delivery systems (BCD). These systems are engineered based on interdisciplinary approaches that combine polymer science, biconjugate chemistry, pharmaceutics, food science and molecular biology and physiology. Many recent studies look into natural ways to harness macronutrients, i.e. proteins, carbohydrates and lipids for efficient delivery of micronutrients and bioactive compounds. To this end, significant advances have been made in respect to the formation and rational design of particulate-based delivery systems. Punctually, we offer here an overview of different biopolymers based nanovehicles constructed and characterized in our lab.The nanovehicles will be generated under different concept, i.e. polyelectrolyte interaction, molecular self-assembly. The encapsulating material was constituted by biopolymers such as chitosan and proteins. The encapsulated material has high impact in nutrition, i.e. bioactive peptides, micronutrients, folic acid, or in biomedicine, insulin, growth factors. These nanostructures do constitute real systems for the encapsulated ligands protection during processing and exerting its controlled release in the body, having on turn the advantages offered by the Nanoscale. Different techniques were used for the molecular characterization of the chemical species, i.e. dynamic laser light scattering (DLS), NMR, FTIR, rheometry. To quantify the encapsulating and encapsulated species interactions, the loading capacity quantification for the designed nanovehicles, complementary approaches were applied, i.e. fluorescence spectroscopy, DLS, zeta potential measurements, etc. High performance microscopy (SEM, AFM) helps us to describe nanovehicles ultrastructure. In-vitro biological impact for the encapsulated ligand was evaluated on appropriate cellular lines.