IQUIBICEN 23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
N-acetylcysteine an antioxidant with antiadipogenic effect in adipocytes
Autor/es:
A PIERALISI; DANIELA SOTO; MATÍAS GABRIELLI; CLAUDIA N. MARTINI, SILVIA G. VAENA DE AVALOS, DAMIÁN G. ROMERO, LEONOR SAN MARTÍN DE VIALE, MARÍA DEL CARMEN VILA; VIRGINIA DIS; FEDERICO ROVNER; MARIA DEL C VILA; JUAN CARLOS CALVO; LILIANA GUERRA
Lugar:
Berlin
Reunión:
Congreso; OCC 2017 World Congress and SFRR-Europe 2017 Annual Conference; 2017
Institución organizadora:
OCC 2017 World Congress and SFRR-Europe 2017 Annual Conference
Resumen:
eports about antioxidant effect in obesity are contradictory. We showedthat N-acetylcysteine (NAC) inhibits cellular lipid accumulation duringadipocyte differentiation, through the inhibition of adipogenictranscriptor factors expression, such as PPARγ and, MAPKsphosphorylation (Pieralisi et al.,Redox Biol 2016; Soto el al,Redox Rep2016). Here we evaluated NAC on fully differentiated cells (3T3-L1adipocytes: AC). Treatments with 0.01 to 5 mM NAC, included in culturemedia for 5 days, were not toxic. 5 mM NAC treatment on AC (ACN) provokeda decrease of 60% in cellular Triglycerides (Tg) content (1.22+0.09 gTg/gprotein [AC] vs 0.49+0.03 gTg/g protein [ACN], p
