IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Role of the signaling of IL-17A on the autophagy process during human tuberculosis
Autor/es:
NICOLÁS O. AMIANO; FLORENCIA CASTELLO; DOMINGO J. PALMERO; JOAQUIN M. PELLEGRINI; MARÍA PAULA MORELLI; NICOLAS CASCO; VERÓNICA E. GARCIA; NANCY TATEOSIAN; AGUSTÍN ROLANDELLI; ALBERTO LEVI; MARÍA ISABEL COLOMBO
Lugar:
Mar del Plata
Reunión:
Congreso; LXIV Reunión Anual de la Sociedad Argentina de Inmunología; 2016
Institución organizadora:
SAIC-SAI-SAFE
Resumen:
An appropriate immune response against Mycobacterium tuberculosis (Mtb) requires Th1 cytokine responses but IFN- alone is not enough to the complete bacterial eradication. Actually, Th17 cells have been associated with Mtb infection. Autophagy is an immune effector mechanism against intracellular pathogens, positively modulated by Th1 cytokines, and negatively regulated by Th2 cytokines. However, the role of other cytokines on autophagy in tuberculosis patients (TB) remains unknown. Here we study the role of IL-17A on autophagy during active human TB. Monocytes (Mo) from TB patients and healthy donors (HD) were infected with Mtb H37Rv pathogenic strain and cultured ± IL-17A (10ng/ml, 24h). Then autophagy levels were analyzed by Flow cytometry and Immunofluorescence Microscopy against LC3-IIB. We observe that IL-17A increased autophagy against Mtb-H37Rv in Mo from HD and TB patients that display strong immunity against Mtb (HR TB; p