Maternal administration of resverastrol protects from lipopolysaccharide-induced preterm labor

DOMÍNGUEZ RUBIO, AP; FRANCHI, AM; CORREA, F; WOLFSON, ML; BARIANI, MV; AISEMBERG, J

Mar del Plata

Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC),; 2016

SAIC

Preterm birth, defined as infants born alive before 37 weeks of pregnancy are completed, is one of the main causes of perinatal morbidity and mortality worldwide. According to the World Health Organization, an estimated 15 million babies are born prematurely every year and this number is rising. This represents 1 in 10 infants globally. Maternal inflammation/infections areamong of the most common causes of preterm onset of labor. We have developed in our lab a murine model of lipopolysaccharide (LPS)-induced preterm labor. Resveratrol, a naturally occurring polyphenol, has been shown to exert anti-inflammatory effects. In the present study, we sought to investigate whether resveratrol was able to prevent the initiation of the preterm labor inducedby LPS, as well as the molecular mechanisms involved. We found that, indeed, resveratrol prevented LPS-induced preterm abor in 64% of the cases. Moreover, maternal administration of resveratrol resulted in a downregulation of LPS-induced proinflammatorymediators such as COX-2 and iNOS (P