IQUIBICEN   23947
INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Electrochemical Graphene Nanoribbons for Electrochemical Determinations of Dopamine and Serotonin
Autor/es:
SACCO, N.; BONETTO, M. C.; CORTÓN, EDUARDO
Lugar:
Valparaiso
Reunión:
Congreso; 10th Ibero-American Congress on Sensors (IBERSENSOR 2016); 2016
Institución organizadora:
Universidad Tecnica Federico Santa Maria, Valparaiso
Resumen:
IntroductionElectrochemically active neurotransmitters such as dopamine (DO), as well as serotonin (5-HT), can be directly detected by electrochemical oxidation, these determinations are of great interest for identification of cognitive dysfunction of neurological diseases such as depression, epilepsy, Parkinson, senile dementia, or squizofrenia as early as possible in order to minimize the deleterious effects and production losses by an essentially young disabled patient population [Willner, 1995; Han et al., 2014]. However the redox behavior of these species at bare electrodes take place at similar potentials than ascorbic acid (AA) and uric acid (UA) which results in rather poor selectivity and reproducibility [Robinson et al., 2008; Venton et al., 2002].Graphene modified electrodes have been employed to overcome these shortcomings. Graphene is a metal-like conductor, but nanoribbons (GNR) can generally be either metallic or semiconducting depending on the patterns formed by their edges [Nakada et al., 1996]. Shinde [2011] has reported an electrochemical approach for transforming MWCNTs to GNRs under ambient conditions simplifying experimental and disposable conditions presented by the Kosynkin/Tour´s longitudinal unzipping method [Kosynkin et al., 2009].We report here for the first time to our knowledge, the simultaneous determination of DO and 5-HT in the presence of AA and UA using a glassy carbon (GC) electrode modified with GNR (GNR/GC) obtained from Shinde´s electrochemical treatment of MWCNT.